Toxic effects of lead exposure in Wistar rats: Involvement of oxidative stress and the beneficial role of edible jute (Corchorus olitorius) leaves

被引：68

作者：

Dewanjee, Saikat ^{[1
]}

Sahu, Ranabir ^{[1
]}

Karmakar, Sarmila ^{[1
]}

Gangopadhyay, Moumita ^{[1
]}

机构：

[1] Jadavpur Univ, Dept Pharmaceut Technol, Adv Pharmacognosy Res Lab, Kolkata 700032, India

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2013年 / 55卷

关键词：

Antioxidant; Corchorus olitorius; Lead toxicity; Oxidative stress; Pb-acetate; FLAVONOID-PEROXIDASE REACTION; DNA-DAMAGE; LIPID-PEROXIDATION; INDUCED APOPTOSIS; PROTECTIVE ROLE; ASCORBIC-ACID; ANTIOXIDANTS; EXTRACT; HYPERLIPIDEMIA; MECHANISMS;

D O I：

10.1016/j.fct.2012.12.040

中图分类号：

TS2 [食品工业];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Lead (Pb) is considered to be a multi-target toxicant. The present study was undertaken to evaluate the protective effect of aqueous extract of Corchorus olitorius leaves against Pb-acetate induced toxic manifestation in blood, liver, kidney, brain and heart of Wistar rats. The Pb-acetate (5 mg/kg body weight) treated rats exhibited a significant inhibition of co-enzymes Q antioxidant enzymes and reduced glutathione levels in the tissues. In addition, the extent of lipid peroxidation, DNA fragmentation and haematological parameters were significantly altered in the Pb-acetate treated rats as compared to control. Simultaneous administration of test extract (25, 50 and 100 mg/kg body weight), could significantly restore the biochemical and haematological parameters near to the normal status through antioxidant activity and/or by preventing bioaccumulation of Pb within the tissues of experimental rats. Presence of substantial quantity of phenolics and flavonoids in the extract may be responsible for the observed protective role against Pb-intoxication. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：78 / 91

页数：14

共 80 条

[1]

Effect of lead toxicity on coenzyme Q levels in rat tissues [J].