Dipasperoside A, a Novel Pyridine Alkaloid-Coupled Iridoid Glucoside from the Roots of Dipsacus asper

被引：19

作者：

Li, Feng ^{[1
]}

Tanaka, Ken ^{[1
]}

Watanabe, Shiro ^{[1
]}

Tezuka, Yasuhiro ^{[1
]}

Saiki, Ikuo ^{[1
]}

机构：

[1] Toyama Univ, Inst Nat Med, Toyama 9300194, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2013年 / 61卷 / 12期

关键词：

Dipsacus asper; dipasperoside A; pyridine alkaloid-coupled iridoid glucoside; nitric oxide production inhibitory activity; FLOWER BUDS; IN-VITRO; SAPONINS; ACID; CONSTITUENTS; WALL;

D O I：

10.1248/cpb.c13-00546

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

A new pyridine alkaloid-coupled iridoid glucoside, dipasperoside A (1), and 20 known compounds (2-21) were isolated from a water extract of Dipsacus asper roots. Compound 1 possessed a unique structural feature with a nicotinic acid nucleus coupled through C-5 with C-7 of a secoiridoid/iridoid glucoside dimer, and esterified with a C-7 hydroxyl group of an iridoid glucoside monomer. All isolates were evaluated for their inhibitory activity against nitric oxide (NO) production in a lipopolysaccharide (LPS)-activated murine macrophage cell line, RAW264.7.

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页码：1318 / 1322

页数：5

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