Xenicane-type diterpenes with cytotoxicity from Xenia florida

被引：16

作者：

Cheng, YB

Jang, JY

Khalil, AT

Kuo, YH

Shen, YC

机构：

[1] Natl Sun Yat Sen Univ, Inst Marine Resources, Kaohsiung 80424, Taiwan

[2] Natl Res Inst Chinese Med, Taipei 112, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 04期

关键词：

D O I：

10.1021/np058110c

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Chromatographic investigation of an acetone extract of the octocoral Xenia florida afforded three new xenicane diterpenes, namely, florxenilide A ( 1), florxenilide B ( 2), and florxenilide C ( 3), in addition to seven known xenicane diterpenes and two known cadinene sesquiterpenes. Structures were elucidated through spectroscopic analysis, especially 2D NMR, and chemical derivatization. The absolute configuration of 1 was determined by NOESY, CD, and Mosher's methods. Florxenilides A ( 1) and B ( 2) exhibited cytotoxicity against human colon cancer (WiDr) cells at 4.5 and 3.7 mu M, respectively.

引用

页码：675 / 678

页数：4

共 17 条

[1] NEW-CALEDONIAN LAGOON MARINE-INVERTEBRATES .9. HAVANNACHLORHYDRINES, NEW METABOLITES OF XENIA-MEMBRANACEA - STRUCTURE AND ABSOLUTE-CONFIGURATION [J].