Oxytrifluoromethylation of multiple bonds using copper catalyst under mild conditions

被引：162

作者：

Egami, Hiromichi ^{[1
,2
]}

Shimizu, Ryo ^{[1
,3
]}

Sodeoka, Mikiko ^{[1
,2
,3
]}

机构：

[1] RIKEN, Adv Sci Inst, Wako, Saitama 3510198, Japan

[2] Japan Sci & Technol Agcy, ERATO, Sodeoka Live Cell Chem Project, Wako, Saitama 3510198, Japan

[3] Saitama Univ, Grad Sch Sci & Engn, Sakura Ku, Saitama 3388570, Japan

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 41期

关键词：

Trifluoromethylation; Copper; Olefin; Alkyne; Togni reagent; ENANTIOSELECTIVE ALPHA-TRIFLUOROMETHYLATION; ELECTROPHILIC TRIFLUOROMETHYLATION; OXIDATIVE TRIFLUOROMETHYLATION; TERMINAL ALKENES; CARBOXYLIC-ACIDS; FLUORINATION; ARYL; PERFLUOROALKYLATION; ALDEHYDES; REAGENT;

D O I：

10.1016/j.tetlet.2012.07.134

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Oxytrifluoromethylation reaction of styrene derivatives and alkynes with external and internal oxygen nucleophiles, catalyzed by copper (1) salts under mild conditions, was developed. Direct formation of a beta-trifluoromethylstyrene derivative from a styrene derivative was also achieved by the reaction in the presence of a Bronsted acid. Further transformation of the oxytrifluoromethylated products was conducted to demonstrate their utility. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：5503 / 5506

页数：4

共 69 条

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