Copper-Mediated Aerobic Oxidative Trifluoromethylation of Terminal Alkynes with Me3SiCF3

被引：256

作者：

Chu, Lingling ^{[1
]}

Qing, Feng-Ling ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

[2] Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai 201620, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 21期

基金：

中国国家自然科学基金;

关键词：

NUCLEOPHILIC TRIFLUOROMETHYLATION; BOND FORMATION; REDUCTIVE ELIMINATION; FACILE SYNTHESES; ORGANIC HALIDES; FLUORINE; FUNCTIONALIZATION; STRATEGIES; ALDEHYDES; IMINES;

D O I：

10.1021/ja102175w

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient copper-mediated trifluoromethylation of terminal alkynes with nucleophilic trifluoromethylating reagent (Me3SiCF3) was developed. Both aromatic alkynes and aliphatic alkynes were effective, and a variety of functionalities such as amino, -OMe, -CO2Et, -Br, and -NO2 were tolerated under the reaction conditions. This reaction provides a general, straightforward, and practically useful method to prepare trifluoromethylated acetylenes.

引用

页码：7262 / +

页数：3

共 54 条

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