Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study

被引：384

作者：

Edison, Paul ^{[1
,2
]}

Archer, Hilary A. ^{[3
]}

Gerhard, Alexander ^{[1
,2
,5
]}

Hinz, Rainer ^{[4
,5
]}

Pavese, Nicola ^{[1
,2
]}

Turkheimer, Federico E. ^{[1
,2
]}

Hammers, Alexander ^{[1
,2
]}

Tai, Yen Fong ^{[1
,2
]}

Fox, Nick ^{[3
]}

Kennedy, Angus ^{[1
,2
]}

Rossor, Martin ^{[1
,2
,3
]}

Brooks, David J. ^{[1
,2
,4
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, MRC, Ctr Clin Sci, London W12 0NN, England

[2] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Div Neurosci, London W12 0NN, England

[3] Inst Neurol, UCL, Dementia Res Ctr, Mainz, Germany

[4] GE Healthcare, Hammersmith Imanet, Mainz, Germany

[5] Univ Manchester, Wolfson Mol Imaging Ctr, Manchester M13 9PL, Lancs, England

来源：

NEUROBIOLOGY OF DISEASE | 2008年 / 32卷 / 03期

基金：

英国医学研究理事会;

关键词：

Alzheimer; Amyloid; Microglia; PIB; PK11195; PET;

D O I：

10.1016/j.nbd.2008.08.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

[11C](R)PK11195-PET is a marker of activated microglia while [11C]PIB-PET detects raised amyloid load. Here we studied in vivo the distributions of amyloid load and microglial activation in Alzheimer's disease (AD) and their relationship with cognitive status. Thirteen AD subjects had [11C](R)PK11195-PET and [11C]PIB-PET scans. Ten healthy controls had [11CI(R)PK]1195-PET and 14 controls had [11C]PIB-PET scans. Region-of-interest analysis of [11C](R)PK11195-PET detected significant 20-35% increases in microglial activation in frontal, temporal, parietal, occipital and cingulate cortices (p<0.05)of the AD subjects. [11C]PIB-PET revealed significant two-fold increases in amyloid load in these same cortical areas (p<0.0001) and SPM (statistical parametric mapping) analysis confirmed the localisation of these increases to association areas. MMSE scores in AD subjects correlated with levels of cortical microglial activation but not with amyloid load. The inverse correlation between MMSE and microglial activation is compatible with a role of microglia in neuronal damage. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：412 / 419

页数：8

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