Phoriospongin A and B:: Two new nematocidal depsipeptides from the Australian marine sponges Phoriospongia sp and Callyspongia bilamellata

被引：37

作者：

Capon, RJ ^{[1
]}

Ford, J

Lacey, E

Gill, JH

Heiland, K

Friedel, T

机构：

[1] Univ Melbourne, Sch Chem, Parkville, Vic 3010, Australia

[2] Microbial Screening Technol Pty Ltd, Kemps Creek, NSW 2171, Australia

[3] Novartis Anim Hlth Australia Pty Ltd, Kemps Creek, NSW 2171, Australia

来源：

JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 03期

关键词：

D O I：

10.1021/np010329d

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioassay-directed fractionation of two southern Australian sponges, Phoriospongia sp. and Callyspongia bilamellata, yielded two new nematocidal depsipeptides, identified as phoriospongins A (1) and B (2). The structures of the phoriospongins were determined by detailed spectroscopic analysis and comparison with the previously reported sponge depsipeptide cyclolithistide A (3), as well as ESIMS and HPLC analysis of acid hydrolysates. It is noteworthy that the unique and yet structurally related metabolites 1-3 are found in sponges spanning three taxonomic orders, Poescilosclerida, Haplosclerida, and Lithistida.

引用

页码：358 / 363

页数：6

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