NIR-Triggered Synergic Photo-chemothermal Therapy Delivered by Reduced Graphene Oxide/Carbon/Mesoporous Silica Nanocookies

被引：93

作者：

Chen, Yu-Wei ^{[1
]}

Chen, Po-Jung ^{[1
]}

Hu, Shang-Hsiu ^{[4
]}

Chen, I-Wei ^{[3
]}

Chen, San-Yuan ^{[1
,2
]}

机构：

[1] Natl Chiao Tung Univ, Dept Mat Sci & Engn, Hsinchu 300, Taiwan

[2] Ind Technol Res Inst, Mat & Chem Res Labs, Hsinchu 31040, Taiwan

[3] Univ Penn, Dept Mat Sci & Engn, Philadelphia, PA 19104 USA

[4] Natl Tsing Hua Univ, Dept Biomed Engn & Environm Sci, Hsinchu 300, Taiwan

来源：

ADVANCED FUNCTIONAL MATERIALS | 2014年 / 24卷 / 04期

关键词：

CONTROLLED DRUG-DELIVERY; MESOPOROUS SILICA; PHOTOTHERMAL THERAPY; GRAPHITE OXIDE; CANCER-THERAPY; IN-SITU; NANOPARTICLES; RELEASE; SHEETS; POLYMERS;

D O I：

10.1002/adfm.201301763

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A novel photo-responsive drug carrier that doubles as a photothermal agent with a nanocookie-like structure is constructed by coating amorphous carbon on a mesoporous silica support self-assembled on a sheet of reduced graphene oxide. With a large payload (0.88 mmolg-1) of a hydrophobic anticancer drug, (S)-(+)-camptothecin (CPT), nanocookies simultaneously provide a burst-like drug release and intense heat upon near-infrared exposure. Being biocompatible yet with a high efficiency for cell uptake, nanocookies have successfully eradicated subcutaneous tumors in 14 days following a single 5 min NIR irradiation without distal damage. These results demonstrate that the nanocookie is an excellent new delivery platform for local, on-demand, NIR-responsive, combined chemotherapy/hyperthermia for tumor treatment and other biomedical applications. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：451 / 459

页数：9

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