Quantum-Dot-Tagged Reduced Graphene Oxide Nanocomposites for Bright Fluorescence Bioimaging and Photothermal Therapy Monitored In Situ

被引：368

作者：

Hu, Shang-Hsiu ^{[1
]}

Chen, Yu-Wei ^{[1
]}

Hung, Wen-Ting ^{[1
]}

Chen, I-Wei ^{[2
]}

Chen, San-Yuan ^{[1
]}

机构：

[1] Natl Chiao Tung Univ, Dept Mat Sci & Engn, Hsinchu 300, Taiwan

[2] Univ Penn, Dept Mat Sci & Engn, Philadelphia, PA 19104 USA

来源：

ADVANCED MATERIALS | 2012年 / 24卷 / 13期

关键词：

quantum dots; graphene; fluorescence; photothermal therapy; nanocomposites; DRUG-DELIVERY; NANOPARTICLES; CANCER; CYTOTOXICITY; ABSORBENCY; IMPACT;

D O I：

10.1002/adma.201104070

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Quantum-dot-tagged reduced graphene oxide (QD-rGO) nanocomposites (left) internalized into targeted tumor cells display bright fluorescence from the QDs (right); by absorbing NIR radiation incident on the rGO and converting it into heat, they also cause simultaneous cell death and fluorescence reduction (bottom). The nanocomposite is thus capable of tumor imaging, photothermal therapy and in situ monitoring of treatment in progress.

引用

收藏

页码：1748 / 1754

页数：7

相关论文

共 35 条

[1]

Barreto J. A., 2006, ADV MATER, V23, pH18

[2]

Quenching of CdSe-ZnS core-shell quantum dot luminescence by water-soluble thiolated ligands [J].

Breus, Vladimir V. ;

Heyes, Colin D. ;

Nienhaus, G. Ulrich .

JOURNAL OF PHYSICAL CHEMISTRY C, 2007, 111 (50) :18589-18594

[3]

Iron oxide nanoparticles as magnetic resonance contrast agent for tumor imaging via folate receptor-targeted delivery [J].

Choi, H ;

Choi, SR ;

Zhou, R ;

Kung, HF ;

Chen, IW .

ACADEMIC RADIOLOGY, 2004, 11 (09) :996-1004

[4]

Fluorescence Resonance Energy Transfer between Quantum Dots and Graphene Oxide for Sensing Biomolecules [J].

Dong, Haifeng ;

Gao, Wenchao ;

Yan, Feng ;

Ji, Hanxu ;

Ju, Huangxian .

ANALYTICAL CHEMISTRY, 2010, 82 (13) :5511-5517

[5]

Impact of Nanotechnology on Drug Delivery [J].

Farokhzad, Omid C. ;

Langer, Robert .

ACS NANO, 2009, 3 (01) :16-20

[6]

CdSe Quantum Dot Sensitized Solar Cells. Shuttling Electrons Through Stacked Carbon Nanocups [J].

Farrow, Blake ;

Kamat, Prashant V. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (31) :11124-11131

[7]

Responsive Supramolecular Gels Constructed by Crown Ether Based Molecular Recognition [J].

Ge, Zhishen ;

Hu, Jinming ;

Huang, Feihe ;

Liu, Shiyong .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (10) :1798-1802

[8]

Cytotoxicity and Phototoxicity of Red Fluorescent Nontargeted Quantum Dots [J].

Generalov, Roman ;

Lukoseviciute, Simona ;

Juzeniene, Asta ;

Juzenas, Petras .

IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS, 2010, 16 (04) :997-1003

[9]

Quantum-dot-tagged microbeads for multiplexed optical coding of biomolecules [J].

Han, MY ;

Gao, XH ;

Su, JZ ;

Nie, S .

NATURE BIOTECHNOLOGY, 2001, 19 (07) :631-635

[10]

Protein adsorption on solid surfaces [J].

Hlady, V ;

Buijs, J .

CURRENT OPINION IN BIOTECHNOLOGY, 1996, 7 (01) :72-77

← 1 2 3 4 →