Applications of LC-MS in the study of the uptake, distribution, metabolism and excretion of bioactive polyphenols from dietary supplements

被引：19

作者：

Barnes, S

Prasain, JK

Wang, CC

Moore, DR

机构：

[1] Univ Alabama Birmingham, Dept Pharmacol & Toxicol, Birmingham, AL 35294 USA

[2] Purdue Univ, Birmingham, AL 35294 USA

[3] Univ Alabama Birmingham, Bot Ctr Agerelated Dis, Birmingham, AL 35294 USA

[4] Univ Alabama Birmingham, Comprehens Canc Ctr Mass Spectrometry Shared Faci, Birmingham, AL 35294 USA

来源：

LIFE SCIENCES | 2006年 / 78卷 / 18期

关键词：

dietary supplements; phytochemicals; polyphenols; psychoactives; tandem mass spectrometry;

D O I：

10.1016/j.lfs.2005.12.002

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Specific and quantitative analyses of the bioactive components and their metabolites in body fluids are essential to assess the interaction between groups of compounds in dietary supplements and preparations of psychoactives. Reverse-phase LC separations combined with tandem mass spectrometry provide the necessary specificity and sensitivity. In this paper, applications of these methods are described for the analysis of isoflavones, salvinorin A, synephrine isomers and their metabolites in serum, urine and aqueous humor. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：2054 / 2059

页数：6

共 14 条

[1] ISOFLAVONES AND THEIR CONJUGATES IN SOY FOODS - EXTRACTION CONDITIONS AND ANALYSIS BY HPLC MASS-SPECTROMETRY [J].