Cutting edge: expression of functional CD137 receptor by dendritic cells

被引:188
作者
Wilcox, RA
Chapoval, AI
Gorski, KS
Otsuji, M
Shin, T
Flies, DB
Tamada, K
Mittler, RS
Tsuchiya, H
Pardoll, DM
Chen, LP
机构
[1] Mayo Clin & Mayo Fdn, Dept Immunol, Rochester, MN 55905 USA
[2] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA
[3] Emory Univ, Sch Med, Carlos & Marguerite Mason Transplantat Biol Res C, Atlanta, GA 30322 USA
[4] Emory Univ, Sch Med, Dept Surg, Atlanta, GA 30322 USA
关键词
D O I
10.4049/jimmunol.168.9.4262
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Interaction between dendritic cells (DCs) and T cells is a prerequisite for the initiation of a T cell response. The molecular nature of this interaction remains to be fully characterized. We report in this work that freshly isolated mouse splenic DCs and bone marrow-derived DCs express CD137 on the cell surface and in soluble form. Triggering CD137 increased the secretion of IL-6 and IL-12 from DCs. More importantly, infusion of an agonistic mAb to CD137 into naive mice enhanced the ability of DCs to stimulate T cell proliferation in response to both alloantigens and a nominal Ag in vitro. This enhancement of DC function is not mediated through activation of T cells, because the effect was also observed in RAG-1 knockout mice that lack T cells. Our findings implicate CD137 as an important receptor involved in the modulation of DC function.
引用
收藏
页码:4262 / 4267
页数:6
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