Perioperative Organ Injury

被引：140

作者：

Bartels, Karsten ^{[1
]}

Karhausen, Joern ^{[1
]}

Clambey, Eric T. ^{[2
]}

Grenz, Almut ^{[2
]}

Eltzschig, Holger K. ^{[2
]}

机构：

[1] Duke Univ, Med Ctr, Dept Anesthesiol, Durham, NC 27710 USA

[2] Univ Colorado Denver, Dept Anesthesiol, Aurora, CO USA

来源：

ANESTHESIOLOGY | 2013年 / 119卷 / 06期

基金：

美国国家卫生研究院;

关键词：

ACUTE KIDNEY INJURY; ACUTE LUNG INJURY; EXTRACORPOREAL MEMBRANE-OXYGENATION; RESPIRATORY-DISTRESS-SYNDROME; ACUTE MYOCARDIAL-INFARCTION; REGULATORY T-CELLS; NONOCCLUSIVE MESENTERIC ISCHEMIA; ANESTHESIA-RELATED MORTALITY; HIGH-FREQUENCY OSCILLATION; INDUCIBLE FACTOR-I;

D O I：

10.1097/ALN.0000000000000022

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Despite the fact that a surgical procedure may have been performed for the appropriate indication and in a technically perfect manner, patients are threatened by perioperative organ injury. For example, stroke, myocardial infarction, acute respiratory distress syndrome, acute kidney injury, or acute gut injury are among the most common causes for morbidity and mortality in surgical patients. In the current review, the authors discuss the pathogenesis of perioperative organ injury, and provide select examples for novel treatment concepts that have emerged over the past decade. Indeed, the authors are of the opinion that research to provide mechanistic insight into acute organ injury and identification of novel therapeutic approaches for the prevention or treatment of perioperative organ injury represent the most important opportunity to improve outcomes of anesthesia and surgery.

引用

页码：1474 / 1489

页数：16

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