Anti-HBs-positive liver failure due to hepatitis B virus reactivation induced by rituximab

被引：95

作者：

Sera, Toshiki ^{[1
]}

Hiasa, Yoichi ^{[1
]}

Michitaka, Kojiro ^{[2
]}

Konishi, Ichiro ^{[1
]}

Matsuura, Kana ^{[1
]}

Tokumoto, Yoshio ^{[1
]}

Matsuura, Bunzo ^{[1
]}

Kajiwara, Takeshi ^{[3
]}

Masumoto, Toshikazu ^{[3
]}

Horiike, Norio ^{[1
]}

Onji, Morikazu ^{[1
]}

机构：

[1] Ehime Univ, Grad Sch Med, Dept Gastroenterol & Metabol, Toon, Japan

[2] Ehime Univ, Grad Sch Med, Dept Endoscop Med, Toon, Japan

[3] Shikoku Canc Ctr, Natl Hosp Org, Toom, Japan

来源：

INTERNAL MEDICINE | 2006年 / 45卷 / 11期

关键词：

hepatitis B virus; reactivation; rituximab;

D O I：

10.2169/internalmedicine.45.1590

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 59-year-old man developed acute hepatitis with reactivated hepatitis B virus (HBV) following administration of rituximab (anti-CD20 monoclonal antibody). The patient was diagnosed with malignant lymphoma in 1998, and virus marker testing indicated HBV surface antigen (HBsAg)-negative and anti-HBs antibody (anti-HBs)-positive results when chemotherapy including rituximab was started. Levels of aminotransferases were elevated, and HBsAg results turned positive. Despite therapy for late-onset hepatic failure, the patient died. Rituximab appears likely to have induced HBV reactivation in this case. Anti-viral agents should be administered for both HBsAg-positive and anti-HBs-positive patients who are scheduled to receive rituximab.

引用

页码：721 / 724

页数：4

共 22 条

[1] Reactivation of hepatitis B in a long-term anti-HBs-positive patient with AIDS following lamivudine withdrawal [J].

Altfeld, M ;

Rockstroh, JK ;

Addo, M ;

Kupfer, B ;

Pult, I ;

Will, H ;

Spengler, U .

JOURNAL OF HEPATOLOGY, 1998, 29 (02) :306-309

[2] Reactivation of hepatitis B after transplantation in patients with pre-existing anti-hepatitis B surface antigen antibodies - Report on three cases and review of the literature [J].

Blanpain, C ;

Knoop, C ;

Delforge, ML ;

Antoine, M ;

Peny, MO ;

Liesnard, C ;

Vereerstraeten, P ;

Cogan, E ;

Adler, M ;

Abramowicz, D .

TRANSPLANTATION, 1998, 66 (07) :883-886

[3] Acute hepatitis B in a patient with antibodies to hepatitis B surface antigen who was receiving rituximab. [J].

Dervite, I ;

Hober, D ;

Morel, P .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (01) :68-69

[4] Sustained improvement in rheumatoid arthritis following a protocol designed to deplete B lymphocytes [J].

Edwards, JCW ;

Cambridge, G .

RHEUMATOLOGY, 2001, 40 (02) :205-211

[5] Fulminant hepatitis B associated with a specific insertion in the basal core promoter region of hepatitis B virus DNA after immunosuppressive treatment [J].

Gérolami, R ;

Henry, M ;

Borentain, P ;

Colson, P ;

Botta, D ;

Tamalet, C .

CLINICAL INFECTIOUS DISEASES, 2005, 40 (04) :E24-E27

[6] Prophylaxis of hepatitis B reactivation using lamivudine in a patient receiving rituximab [J].

Hamaki, T ;

Kami, M ;

Kusumi, E ;

Ueyama, J ;

Miyakoshi, S ;

Morinaga, S ;

Mutou, Y .

AMERICAN JOURNAL OF HEMATOLOGY, 2001, 68 (04) :292-294

[7] REACTIVATION OF HEPATITIS-B VIRUS-REPLICATION IN PATIENTS RECEIVING CYTOTOXIC THERAPY - REPORT OF A PROSPECTIVE-STUDY [J].

LOK, ASF ;

LIANG, RHS ;

CHIU, EKW ;

WONG, KL ;

CHAN, TK ;

TODD, D .

GASTROENTEROLOGY, 1991, 100 (01) :182-188

[8] B cells as therapeutic targets for rheumatic diseases [J].

Looney, RJ ;

Anolik, J ;

Sanz, I .

CURRENT OPINION IN RHEUMATOLOGY, 2004, 16 (03) :180-185

[9] Reactivation of latently infected hepatitis B virus in a leukemia patient with antibodies to hepatitis B core antigen [J].

Marusawa, H ;

Imoto, S ;

Ueda, Y ;

Chiba, T .

JOURNAL OF GASTROENTEROLOGY, 2001, 36 (09) :633-636

[10] THE SEROLOGY OF CHRONIC HEPATITIS-B INFECTION REVISITED [J].

MARUYAMA, T ;

MCLACHLAN, A ;

IINO, S ;

KOIKE, K ;

KUROKAWA, K ;

MILICH, DR .

JOURNAL OF CLINICAL INVESTIGATION, 1993, 91 (06) :2586-2595

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