Synthesis and in vitro and in vivo evaluation of the 2-(6′methoxy-3′,4′dihydro-1′-naphtyl)-4H-3,1-benzoxazin-4-one as a new potent substrate inhibitor of human leukocyte elastase

被引：15

作者：

Arcadi, A

Asti, C

Brandolini, L

Caselli, G

Marinelli, F

Ruggieri, V

机构：

[1] Univ Aquila, Dipartimento Chim Ingn Chim & Mat, I-67100 Laquila, Italy

[2] Dompe Res Ctr, I-67100 Laquila, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(99)00168-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

the title 2-vinyl-4H-3,1-benzoxazin-4-one has been synthesised and tested for inhibitory activity against human leukocyte elastase. The compound has shown activity both in vitro towards human sputum elastase and in vivo in an hemorrhagic assay. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：1291 / 1294

页数：4

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