Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12

被引：135

作者：

Sun, Jielin ^{[2
,3
]}

Zheng, Siqun Lilly ^{[2
,3
]}

Wiklund, Fredrik ^{[1
]}

Isaacs, Sarah D. ^{[4
]}

Purcell, Lina D. ^{[2
,3
]}

Gao, Zhengrong ^{[2
,3
]}

Hsu, Fang-Chi ^{[2
,5
]}

Kim, Seong-Tae ^{[2
,3
]}

Liu, Wennuan ^{[2
,3
]}

Zhu, Yi ^{[2
,3
]}

Stattin, Paer ^{[6
]}

Adami, Hans-Olov ^{[1
,7
]}

Wiley, Kathleen E. ^{[4
]}

Dimitrov, Latchezar ^{[2
,3
]}

Sun, Jishan ^{[2
,3
]}

Li, Tao ^{[2
,3
]}

Turner, Aubrey R. ^{[2
,3
]}

Adams, Tamara S. ^{[2
,3
]}

Adolfsson, Jan ^{[8
]}

Johansson, Jan-Erik ^{[9
]}

Lowey, James ^{[10
]}

Trock, Bruce J. ^{[4
]}

Partin, Alan W. ^{[4
]}

Walsh, Patrick C. ^{[4
]}

Trent, Jeffrey M. ^{[10
]}

Duggan, David ^{[10
]}

Carpten, John ^{[10
]}

Chang, Bao-Li ^{[2
,3
]}

Gronberg, Henrik ^{[1
]}

Isaacs, William B. ^{[4
]}

Xu, Jianfeng ^{[2
,3
]}

机构：

[1] Karolinska Inst, CLINTEC, Dept Med Epidemiol & Biostat, SE-17177 Stockholm, Sweden

[2] Wake Forest Univ, Bowman Gray Sch Med, Ctr Canc Genom, Winston Salem, NC 27157 USA

[3] Wake Forest Univ, Bowman Gray Sch Med, Ctr Human Genom, Winston Salem, NC 27157 USA

[4] Johns Hopkins Med Inst, Dept Urol, Baltimore, MD 21287 USA

[5] Wake Forest Univ, Bowman Gray Sch Med, Dept Biostat Sci, Winston Salem, NC 27157 USA

[6] Umea Univ Hosp, Dept Surg & Perioperat Sci, SE-90787 Umea, Sweden

[7] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[8] Karolinska Inst, CLINTEC, Ctr Oncol, SE-17177 Stockholm, Sweden

[9] Orebro Univ Hosp, Dept Urol, SE-70182 Orebro, Sweden

[10] Translat Genom Res Inst, Phoenix, AZ 85004 USA

来源：

NATURE GENETICS | 2008年 / 40卷 / 10期

基金：

瑞典研究理事会;

关键词：

D O I：

10.1038/ng.214

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, similar to 26 kb centromeric to the first known locus (rs4430796); these loci are separated by a recombination hot spot. We confirmed the association with a SNP in the second locus (rs11649743) in five additional populations, with P = 1.7 x 10(-9) for an allelic test of the seven studies combined. The association at each SNP remained significant after adjustment for the other SNP.

引用

页码：1153 / 1155

页数：3

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