Antibiotic resistance in a very remote Amazonas community

被引：65

作者：

Bartoloni, Alessandro ^{[1
]}

Pallecchi, Lucia ^{[3
]}

Rodriguez, Hugo ^{[2
]}

Fernandez, Connie ^{[2
]}

Mantella, Antonia ^{[1
]}

Bartalesi, Filippo ^{[1
]}

Strohmeyer, Marianne ^{[1
]}

Kristiansson, Charlotte ^{[4
]}

Gotuzzo, Eduardo ^{[5
]}

Paradisi, Franco ^{[1
]}

Rossolini, Gian Maria ^{[3
]}

机构：

[1] Univ Florence, Osped Careggi, Dipartimento Area Crit Med Chirurg, Clin Malattie Infett, I-50134 Florence, Italy

[2] Hosp Apoyo Yurimaguas, Yurimaguas Loreto, Peru

[3] Univ Siena, Dipartimento Biol Mol, Sez Microbiol, I-53100 Siena, Italy

[4] Karolinska Inst, Div Int Hlth IHCAR, Dept Publ Hlth Sci, S-17176 Stockholm, Sweden

[5] Univ Peruana Cayetano Heredia, Inst Med Trop Alexander von Humboldt, Lima 100, Peru

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2009年 / 33卷 / 02期

关键词：

Escherichia coli; Antibiotic resistance; Commensal bacteria; Remote community; Peruvian Amazonas; COMMENSAL ESCHERICHIA-COLI; ANTIMICROBIAL RESISTANCE; ANTIBACTERIAL RESISTANCE; BACTERIA; PERSISTENCE; BOLIVIA; GENES; PERU;

D O I：

10.1016/j.ijantimicag.2008.07.029

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

In a very remote human community of the Peruvian Amazonas with minimal antibiotic exposure, high levels of acquired resistance to the oldest antibiotics ( ampicillin, tetracycline, trimethoprim/sulfamethoxazole, streptomycin and chloramphenicol) were detected in commensal Escherichia coli, with remarkable diversity of resistant clones and of resistance genes and plasmids. This pattern was similar overall to that previously observed in a very remote community of Bolivia. It was also similar to that observed in the nearest urban area, except for a lower dominance of resistant isolates and the absolute lack of quinolone resistance in the remote community. Present findings suggest that antibiotic resistance observed in remote communities with minimal antibiotic exposure is a general phenomenon contributed by complex mechanisms and provide new insights into the mechanisms involved in this phenomenon. (C) 2008 Elsevier B. V. and the International Society of Chemotherapy. All rights reserved.

引用

页码：125 / 129

页数：5

共 27 条

[21] Why are antibiotic resistance genes so resistant to elimination? [J].

Salyers, AA ;

AmabileCuevas, CF .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (11) :2321-2325

[22]

Sambrook JF., 2001, MOL CLONING LAB MANU

[23] Dissemination of multildrug-resistant bacteria into the Arctic [J].

Sjolund, Maria ;

Bonnedahl, Jonas ;

Hernandez, Jorge ;

Bengtsson, Stina ;

Cederbrant, Gunilla ;

Pinhassi, Jarone ;

Kahlmeter, Gunnar ;

Olsen, Bjoern .

EMERGING INFECTIOUS DISEASES, 2008, 14 (01) :70-72

[24]

Souza V, 1999, APPL ENVIRON MICROB, V65, P3373

[25] Carriage of antibiotic-resistant fecal bacteria in nepal reflects proximity to Kathmandu [J].

Walson, JL ;

Marshall, B ;

Pokhrel, BM ;

Kafle, KK ;

Levy, SB .

JOURNAL OF INFECTIOUS DISEASES, 2001, 184 (09) :1163-1169

[26]

*WHO, 1993, TREATM PREV AC DIARR

[27]

Wikler M., 2007, M100-S17, V27, P1

← 1 2 3 →