The role of osteopontin in breast cancer: Clinical and experimental studies

被引：128

作者：

Tuck, AB

Chambers, AF

机构：

[1] London Reg Canc Ctr, London, ON N6A 4L6, Canada

[2] Univ Western Ontario, Dept Oncol, London, ON, Canada

[3] Univ Western Ontario, Dept Pathol, London, ON, Canada

[4] London Hlth Sci Ctr, Dept Pathol, London, ON, Canada

来源：

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA | 2001年 / 6卷 / 04期

关键词：

breast cancer; malignancy; osteopontin; experimental studies; clinical studies; prognostic factor;

D O I：

10.1023/A:1014734930781

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Osteopontin (OPN) is a secreted, integrin-binding protein which has been implicated in cancer, as well as other pathologies and some aspects of normal development. Here we focus on the role of OPN in breast cancer. We describe studies that have shown that OPN plays a role in normal mammary gland development as well as in progression of breast cancer. We also summarize studies that have shown that OPN can play a functional role in malignancy of breast cancer. At least some of these effects are mediated by specific cell surface integrins (alphavbeta3 vs. alphavbeta1 and alphavbeta5) and lead to increased cell migration, activation of growth factor/receptor pathways (e.g. HGF and EGF), and increased proteolytic enzyme activity (e.g. uPA). We also summarize clinical studies that show that OPN levels in tumors and blood are elevated in women with metastatic breast cancer and may offer promise as prognostic markers in breast cancer.

引用

页码：419 / 429

页数：11

共 96 条

[21] IDENTIFICATION OF THE MAJOR PHOSPHOPROTEIN SECRETED BY MANY RODENT CELL-LINES AS 2AR/OSTEOPONTIN - ENHANCED EXPRESSION IN H-RAS-TRANSFORMED 3T3 CELLS [J].