Making connections: the development of mesencephalic dopaminergic neurons

被引：47

作者：

Riddle, R ^{[1
]}

Pollock, JD ^{[1
]}

机构：

[1] Natl Inst Drug Abuse, Genet & Mol Neurobiol Res Branch, Div Neurosci & Behav Res, Bethesda, MD 20892 USA

来源：

DEVELOPMENTAL BRAIN RESEARCH | 2003年 / 147卷 / 1-2期

关键词：

dopamine neuron; mesencephalon; development; embryogenesis; transcription factor; growth factor; proliferation; early patterning; early neurite specification; process outgrowth; navigation; target selection; axonal guidance; synapse maturation; substantia nigra; ventral tegmental area; Parkinson's disease; substance abuse; addiction; GLIAL-CELL LINE; ORPHAN NUCLEAR RECEPTOR; NAIL-PATELLA SYNDROME; PRENATAL COCAINE EXPOSURE; HYDROXYLASE-IMMUNOREACTIVE NEURONS; METABOTROPIC GLUTAMATE RECEPTORS; CENTRAL-NERVOUS-SYSTEM; RETINOID-X-RECEPTOR; GDNF FAMILY LIGANDS; LIM-HOMEOBOX GENES;

D O I：

10.1016/j.devbrainres.2003.09.010

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The disorders of two adjacent sets of mesencephalic dopaminergic neurons (MDNs) are associated with two significant health problems: Parkinson's disease and drug addiction. Because of this, a great deal of research has focused on understanding the growth, development and maintenance of MDNs. Many transcription factors and signaling pathways are known to be required for normal MDNs formation, but a unified model of MDN development is still unclear. The long-term goal is to design therapeutic strategies to: (i) nurture and/or heal endogenous MDNs, (ii) replace the affected tissue with exogenous MDNs from in vitro cultivated stem cells and (iii) restore normal connectivity. Recent developmental biology studies show great promise in understanding how MDNs develop both in vivo and in vitro. This information has great therapeutic value and may provide insight into how environmental and genetic factors increase vulnerability to addiction. (C) 2003 Elsevier B.V All rights reserved.

引用

页码：3 / 21

页数：19

共 208 条

[21] Dopamine biosynthesis is selectively abolished in substantia nigra ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene [J].