Enhancement of calcyclin gene RNA expression in squamous cell carcinoma of the oral mucosa, but not in benign lesions

被引：19

作者：

Berta, GN ^{[1
]}

Ghezzo, F ^{[1
]}

DAvolio, A ^{[1
]}

Zulian, P ^{[1
]}

Carbone, V ^{[1
]}

Racca, S ^{[1
]}

Vercellino, V ^{[1
]}

DiCarlo, F ^{[1
]}

机构：

[1] UNIV TURIN, DEPT CLIN & BIOL SCI, TURIN, ITALY

来源：

JOURNAL OF ORAL PATHOLOGY & MEDICINE | 1997年 / 26卷 / 05期

关键词：

calcyclin; oral cancer; PCR; proliferation gene;

D O I：

10.1111/j.1600-0714.1997.tb01225.x

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Oral cancer is a neoplasm with some known causes. Proliferation genes are significant among its few pathogenetic and prognostic factors. Calcyclin is a cell-cycle-related gene, the function of which is still unclear. Its expression and that of Ha-ras and histone-H3 have been investigated in an assessment of their pathogenetic role in squamous cell carcinoma. RNA extracted from the pathological and normal mucosa of patients with squamous cell carcinoma (SCC) and benign lesions was reverse transcribed and amplified by the polymerase chain reaction (PCR). The expression of all three genes in the pathological mucosa was enhanced in SCC only. This suggests that they may be involved in its pathogenesis and provides another parameter for the differentiation of malignant and benign lesions.

引用

页码：206 / 210

页数：5

共 44 条

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