Pathogenicity of highly pathogenic avian influenza virus in mammals

被引：38

作者：

de Wit, Emmie ^{[1
,2
]}

Kawaoka, Yoshihiro ^{[3
,4
]}

de Jong, Menno D. ^{[5
]}

Fouchier, Ron A. M. ^{[1
,2
]}

机构：

[1] Erasmus MC, Dept Virol, POB 2040, NL-3000 CA Rotterdam, Netherlands

[2] Erasmus MC, Natl Influenza Ctr, NL-3000 CA Rotterdam, Netherlands

[3] Univ Wisconsin, Sch Vet Med, Dept Pathobiol Sci, Madison, WI 53706 USA

[4] Univ Tokyo, Inst Med Sci, Int Res Ctr Infect Dis, Dept Microbiol & Immunol,Dept Virol, Tokyo 1088639, Japan

[5] Univ Oxford, Clin Res Unit, Hosp Trop Dis, Ho Chi Minh City, Vietnam

来源：

VACCINE | 2008年 / 26卷

关键词：

Influenza A virus; Pathogenicity; HPAI;

D O I：

10.1016/j.vaccine.2008.07.072

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In recent years, there has been an increase in outbreaks of highly pathogenic avian influenza (HPAI) in poultry. Occasionally, these outbreaks have resulted in transmission of influenza viruses to humans and other mammals, with symptoms ranging from conjunctivitis to pneumonia and death. Here the current, knowledge of the determinants of pathogenicity of HPAI viruses in mammals is summarized. It is becoming apparent that common mechanisms exist across influenza A virus strains and subtypes, through which influenza viruses adapt to mammals and gain or loose pathogenicity. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：D54 / D58

页数：5

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