LHMDS mediated tandem acylation-cyclization of 2-aminobenzenecarbonitriles with 2-benzymidazol-2-yl acetates: a short and efficient route to the synthesis of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones

被引：6

作者：

Antonios-McCrea, WR ^{[1
]}

Frazier, KA ^{[1
]}

Jazan, EM ^{[1
]}

Machajewski, TD ^{[1
]}

McBride, CM ^{[1
]}

Pecchi, S ^{[1
]}

Renhowe, PA ^{[1
]}

Shafer, CM ^{[1
]}

Taylor, C ^{[1
]}

机构：

[1] Chiron Corp, Small Mol Drug Discovery, Med Chem Dept, Emeryville, CA 94608 USA

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 05期

关键词：

receptor tyrosine kinases (RTK); 4-amino-3-benzimidazol-2-ylhydroquinotin-2-one; tandem acylation-cyclization; LHMDS;

D O I：

10.1016/j.tetlet.2005.11.113

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We herein describe the discovery of a mild, one-pot tandem acylation-cyclization for the synthesis of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones from 2-aminobenzenecarbonitriles and ethyl 2-benzimidazol-2-yl acetates. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：657 / 660

页数：4

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