Identification and characterization of Huntington related pathology: An in vivo DKI imaging study

被引：30

作者：

Blockx, Ines ^{[1
]}

Verhoye, Marleen ^{[1
]}

Van Audekerke, Johan ^{[1
]}

Bergwerf, Irene ^{[5
]}

Kane, Jack X. ^{[4
]}

Delgado y Palacios, Rafael ^{[1
]}

Veraart, Jelle ^{[2
]}

Jeurissen, Ben ^{[2
]}

Raber, Kerstin ^{[3
]}

von Hoersten, Stephan ^{[3
]}

Ponsaerts, Peter ^{[5
]}

Sijbers, Jan ^{[2
]}

Leergaard, Trygve B. ^{[4
]}

Van der Linden, Annemie ^{[1
]}

机构：

[1] Univ Antwerp, Bioimaging Lab, Univ Pl 1, B-2610 Antwerp, Belgium

[2] Univ Antwerp, Vis Lab, B-2610 Antwerp, Belgium

[3] Univ Erlangen Nurnberg, D-91054 Erlangen, Germany

[4] Univ Oslo, Inst Basic Med Sci, Ctr Mol Biol & Neurosci, N-0316 Oslo, Norway

[5] Univ Antwerp, Lab Expt Hematol, B-2020 Antwerp, Belgium

来源：

NEUROIMAGE | 2012年 / 63卷 / 02期

关键词：

Neuroimaging; Diffusional kurtosis imaging; Diffusion tensor imaging; Glia; Transgenic rat model; Huntington disease; TRANSGENIC RAT MODEL; GAUSSIAN WATER DIFFUSION; FRACTIONAL ANISOTROPY; TENSOR MRI; DISEASE; BRAIN; DYSFUNCTION; SYMPTOMS; TISSUES; MENINGITIS;

D O I：

10.1016/j.neuroimage.2012.06.032

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

An important focus of Huntington Disease (HD) research is the identification of symptom-independent biomarkers of HD neuropathology. There is an urgent need for reproducible, sensitive and specific outcome measures, which can be used to track disease onset as well as progression. Neuroimaging studies, in particular diffusion-based MRI methods, are powerful probes for characterizing the effects of disease and aging on tissue microstructure. We report novel diffusional kurtosis imaging (DKI) findings in aged transgenic HD rats. We demonstrate altered diffusion metrics in the (pre)frontal cerebral cortex, external capsule and striatum. Presence of increased diffusion complexity and restriction in the striatum is confirmed by an increased fiber dispersion in this region. Immunostaining of the same specimens reveals decreased number of microglia in the (pre)frontal cortex, and increased numbers of oligodendrocytes in the striatum. We conclude that DKI allows sensitive and specific characterization of altered tissue integrity in this HD rat model, indicating a promising potential for diagnostic imaging of gray and white matter pathology. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：653 / 662

页数：10

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