Tuning the aggregation behaviour of single-chain bolaphospholipids in aqueous suspension: from nanoparticles to nanofibres to lamellar phases

被引：22

作者：

Blume, Alfred ^{[1
]}

Drescher, Simon ^{[1
,3
]}

Meister, Annette ^{[2
]}

Graf, Gesche ^{[1
]}

Dobner, Bodo ^{[4
]}

机构：

[1] Univ Halle Wittenberg, Inst Chem Phys Chem, D-06120 Halle, Germany

[2] Univ Halle Wittenberg, ZIK HALOmem Membrane Struct & Dynam, D-06120 Halle, Germany

[3] Univ Halle Wittenberg, Inst Pharm Pharmaceut Chem, D-06120 Halle, Germany

[4] Univ Halle Wittenberg, Inst Pharm Biochem Pharm, D-06120 Halle, Germany

来源：

FARADAY DISCUSSIONS | 2013年 / 161卷

关键词：

AIR-WATER-INTERFACE; HELICAL NANOFIBERS; GENERAL-SYNTHESIS; MIXING BEHAVIOR; BOLAAMPHIPHILE; HYDROGELS; PHOSPHOLIPIDS; PH;

D O I：

10.1039/c2fd20102j

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The aggregation behaviour in aqueous suspensions of symmetrical bipolar phospholipids (bolalipids) composed of one long alkyl chain and two polar headgroups were studied as a function of their chemical structure, i.e. the length of their chain, the modification of the chain by introduction of hetero-atoms, triple bonds, or phenyl rings, and the size of the headgroups. Three types of aggregate structures are formed by these bolalipids, namely helical nanofibres, micelle-like aggregates and lamellar sheets. The type of aggregate formed depends not only on the chemical structure, particularly the ratio of the cross-sectional area of the headgroup and the chain, but also on the presence of attractive interactions via hydrogen bonds or repulsive electrostatic interactions between the headgroups.

引用

页码：193 / 213

页数：21

共 22 条

[1] BIOLOGICAL CALORIMETRY - MEMBRANES [J].

BLUME, A .

THERMOCHIMICA ACTA, 1991, 193 :299-347

[2]

Blume A., 1999, In the handbook of thermal analysis and calorimetry, V4, P109

[3]

Cevc G., 1993, PHOSPHOLIPID HDB

[4] General synthesis and aggregation behaviour of new single-chain bolaphospholipids: Variations in chain and headgroup structures [J].

Drescher, Simon ;

Meister, Annette ;

Graf, Gesche ;

Hause, Gerd ;

Blume, Alfred ;

Dobner, Bodo .

CHEMISTRY-A EUROPEAN JOURNAL, 2008, 14 (22) :6796-6804

[5] General synthesis and aggregation behaviour of a series of single-chain 1,ω-bis(phosphocholines) [J].

Drescher, Simon ;

Meister, Annette ;

Blume, Alfred ;

Karlsson, Goran ;

Almgren, Mats ;

Dobner, Bodo .

CHEMISTRY-A EUROPEAN JOURNAL, 2007, 13 (18) :5300-5307

[6] Amino-functionalized single-chain bolalipids: Synthesis and aggregation behavior of new basic building blocks [J].

Drescher, Simon ;

Graf, Gesche ;

Hause, Gerd ;

Dobner, Bodo ;

Meister, Annette .

BIOPHYSICAL CHEMISTRY, 2010, 150 (1-3) :136-143

[7]

Graf G., 2011, THESIS MARTIN LUTHER

[8] Self-Assembled Bolaamphiphile Fibers Have Intermediate Properties between Crystalline Nanofibers and Wormlike Micelles: Formation of Viscoelastic Hydrogels Switchable by Changes in pH and Salinity [J].

Graf, Gesche ;

Drescher, Simon ;

Meister, Annette ;

Dobner, Bodo ;

Blume, Alfred .

JOURNAL OF PHYSICAL CHEMISTRY B, 2011, 115 (35) :10478-10487

[9]

Israelachvili JN, 2011, INTERMOLECULAR AND SURFACE FORCES, 3RD EDITION, P1

[10] Temperature-dependent aggregation behavior of symmetric long-chain bolaamphiphiles at the air-water interface [J].

Köhler, K ;

Meister, A ;

Dobner, B ;

Drescher, S ;

Ziethe, F ;

Blume, A .

LANGMUIR, 2006, 22 (06) :2668-2675

← 1 2 3 →