Synthesis of phosphorofluoridate analogues of myo-inositol 1,4,5-tris(phosphate) and their biological activity

被引：4

作者：

Watanabe, Y ^{[1
]}

Sofue, S ^{[1
]}

Ozaki, S ^{[1
]}

Hirata, M ^{[1
]}

机构：

[1] KYUSHU UNIV,FAC DENT,DEPT BIOCHEM,FUKUOKA 812,JAPAN

来源：

CHEMICAL COMMUNICATIONS | 1996年 / 15期

关键词：

D O I：

10.1039/cc9960001815

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Phosphorofluoridate analogues of myo-inositol 1,4,5-tris(phosphate), 4- and 5-phosphorofluoridate and 4,5-bis(phosphorofluoridate), were prepared and their biological activity towards InsP(3) 5-phosphatase was found to be similar to or more active than that for InsP(3) while they proved to be less active in the binding assay than InsP(3).

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页码：1815 / 1816

页数：2

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