Pharmacokinetic study of arctigenin in rat plasma and organ tissue by RP-HPLC method

被引：25

作者：

He, Fan ^{[1
]}

Dou, De-Qiang ^{[2
]}

Hou, Qiang ^{[1
]}

Sun, Yu ^{[1
]}

Kang, Ting-Guo ^{[3
]}

机构：

[1] Liaoning Univ Tradit Chinese Med, Coll Pharm, Dalian, Peoples R China

[2] Liaoning Univ Tradit Chinese Med, Dept Chem, TCM, Dalian, Peoples R China

[3] Liaoning Univ Tradit Chinese Med, Dept Pharmacognosy, Dalian, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2013年 / 27卷 / 10期

关键词：

pharmacokinetics; distribution; arctigenin; HPLC; ARCTIIN; IDENTIFICATION; L;

D O I：

10.1080/14786419.2012.666745

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

A high-performance liquid chromatography (HPLC) technique was developed for the determination of arctigenin in plasma and various organs of rats after the oral administration of 30, 50 and 70mgkg(-1) of arctigenin to the Sprague-Dawley rats. Results showed that the validated HPLC method was simple, fast, reproducible and suitable to the determination of arctigenin in rat plasma and organ tissue and one-compartmental model with zero-order absorption process can well describe the changes of arctigenin concentration in the plasma. The concentration of compound was highest in the spleen, less in the liver and the least in the lung.

引用

页码：903 / 906

页数：4

共 7 条

[1]

Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation [J].