Loss of SUMO1 in mice affects RanGAP1 localization and formation of PML nuclear bodies, but is not lethal as it can be compensated by SUMO2 or SUMO3

被引:123
作者
Evdokimov, Evgenij [1 ]
Sharma, Prashant [1 ]
Lockett, Stephen J. [2 ]
Lualdi, Margaret [3 ]
Kuehn, Michael R. [1 ]
机构
[1] NCI, Lab Prot Dynam & Signaling, NIH, Frederick, MD 21702 USA
[2] SAIC Frederick, Adv Technol Program, Opt Microscopy & Anal Lab, Frederick, MD 21702 USA
[3] SAIC Frederick, Lab Anim Sci Program, Frederick, MD 21702 USA
关键词
SUMO; RanGAP1; PML;
D O I
10.1242/jcs.038570
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Conjugation of the small ubiquitin-like modifier (SUMO) to target proteins regulates numerous biological processes and has been implicated in tumorigenesis and metastasis. The three SUMO isoforms in vertebrates, SUMO1 and the highly similar SUMO2 and SUMO3, can be conjugated to unique as well as overlapping subsets of target proteins. Yet, it is still not clear whether roles for each family member are distinct or whether redundancy exists. Here we describe a mutant mouse line that completely lacks SUMO1, but surprisingly is viable and lacks any overt phenotype. Our study points to compensatory utilization of SUMO2 and/or SUMO3 for sumoylation of SUMO1 targets. The ability of SUMO isoforms to substitute for one another has important implications for rational targeting of the SUMO pathway.
引用
收藏
页码:4106 / 4113
页数:8
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