Tag-team SUMO wrestling

被引：4

作者：

Duda, DM

Schulman, BA

机构：

[1] St Jude Childrens Res Hosp, Dept Struct Biol, Memphis, TN 38105 USA

[2] St Jude Childrens Res Hosp, Dept Genet & Tumor Cell Biol, Memphis, TN 38105 USA

来源：

MOLECULAR CELL | 2005年 / 18卷 / 06期

关键词：

D O I：

10.1016/j.molcel.2005.05.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Structural and kinetic studies of a SUMORanGAP1-Ubc9-Nup358/RanBP2 complex (Reverter and Lima, 2005) provide the first high-resolution view of SUMO recognition by a SUMO binding motif and also reveal a novel mechanism for E3 ubiquitin-like protein ligases, with the Nup358/RanBP2 E3 teaming up with both SUMO and the E2 (Ubc9) to stimulate tagging.

引用

收藏

页码：612 / 614

页数：3

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