Sero-epidemiology of Bordetella pertussis in England and Wales

被引：35

作者：

Nardone, A

Pebody, RG

Maple, PAC

Andrews, N

Gay, NJ

Miller, E

机构：

[1] Hlth Protect Agcy, Ctr Communicable Dis Surveillance, Immunisat Div, London NW9 5EQ, England

[2] Hlth Protect Agcy SW, Dept Virol, Bristol, Avon, England

[3] Hlth Protect Agcy, Ctr Communicable Dis Surveillance, Modelling & Econ Unit, London, England

来源：

VACCINE | 2004年 / 22卷 / 9-10期

关键词：

pertussis; sero-epidemiology; UK;

D O I：

10.1016/j.vaccine.2003.08.039

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The incidence of pertussis infection can be estimated in the population by defining a single high titre of anti pertussis toxin (PT) immunoglobulin G (IgG) antibody predictive of recent infection. Sera samples collected in 1986, 1996 or annually between 1987 and 1998 were tested for anti-PT IgG antibody. In 1996, the age-adjusted prevalence of pertussis infection was 1.2% and was higher in children than in adults. Amongst samples collected annually, older age and female sex, but none of the temporal variables, were associated with a serologically defined pertussis infection. There is an important incidence of infection in the population, which is greater amongst children than adults, but there is only limited evidence of a correlation with epidemic cycles. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：1314 / 1319

页数：6

共 27 条

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