In vivo bio-distribution of intravenously injected Tc-99 m labeled ferrite nanoparticles bounded with biocompatible medicals

被引：20

作者：

Fu, CM ^{[1
]}

Wang, YF

Guo, YF

Lin, TY

Chiu, JS

机构：

[1] Natl Univ Kaohsiung, Dept Appl Phys, Kaohsiung 811, Taiwan

[2] Natl Kaohsiung Normal Univ, Dept Phys, Kaohsiung 824, Taiwan

[3] Buddish Dalian TzuChi Gen Hosp, Dept Nucl Med, Chiayi 622, Taiwan

来源：

IEEE TRANSACTIONS ON MAGNETICS | 2005年 / 41卷 / 10期

关键词：

bio-distribution; ferrites; nano-particles; nuclear imaging; radioisotopes;

D O I：

10.1109/TMAG.2005.855335

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 [电气工程]; 0809 [电子科学与技术];

摘要：

In vivo bio-distribution of directly radioisotope (Tc-99 m) labeled with ferrite (Fe3O4) nanoparticles, conjugated with Poly(ethyelene glycol) (PEG), upon intravenous injection into rats was studied. The time evolution of bio-distribution of the radio-beads was investigated by analyzing the scintigrams monitored with a planar gamma camera. From the scintigraphic images, the PEG conjugated ferrite radiobeads have demonstrated a reduction of uptake by organs. Whereas, the ferrite-radiobeads have shown a fast and great uptake by the liver during the first few blood circulations. Therapeutic applications by further conjugation of the ferrite radiobeads with herb medicals, such as Gentiana combination and Trionyx sinensis, are feasible.

引用

页码：4120 / 4122

页数：3

共 13 条

[1]

FERRITE-PLATING IN AQUEOUS-SOLUTION - A NEW METHOD FOR PREPARING MAGNETIC THIN-FILM [J].

ABE, M ;

TAMAURA, Y .

JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS, 1983, 22 (08) :L511-L513

[2]

Directly labeling ferrite nanoparticles with Tc-99m radioisotope for diagnostic applications [J].

Fu, CM ;

Wang, YF ;

Chao, YC ;

Hung, SH ;

Yang, MD .

IEEE TRANSACTIONS ON MAGNETICS, 2004, 40 (04) :3003-3005

[3]

GREF R, 2003, SYNTHESIS FUNCTIONAL, P233

[4]

HAFELI UO, 1994, J BIOMED MATER RES, V28, P901

[5]

EFFECTIVE TARGETING OF MAGNETIC RADIOACTIVE Y-90 MICROSPHERES TO TUMOR-CELLS BY AN EXTERNALLY APPLIED MAGNETIC-FIELD - PRELIMINARY IN-VITRO AND IN-VIVO RESULTS [J].

HAFELI, UO ;

SWEENEY, SM ;

BERESFORD, BA ;

HUMM, JL ;

MACKLIS, RM .

NUCLEAR MEDICINE AND BIOLOGY, 1995, 22 (02) :147-155

[6]

In vitro and in vivo toxicity of magnetic microspheres [J].

Häfeli, UO ;

Pauer, GJ .

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 1999, 194 (1-3) :76-82

[7]

Development of magnetic device for cell separation [J].

Haik, Y ;

Pai, V ;

Chen, CJ .

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 1999, 194 (1-3) :254-261

[8]

IKEDA MO, 2004, IEEE T MAGN, V40, P3018

[9]

Jordan A, 1997, SCIENTIFIC AND CLINICAL APPLICATIONS OF MAGNETIC CARRIERS, P569

[10]

Lubbe AS, 1996, CANCER RES, V56, P4694

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