Identification of plant microRNA homologs

被引：93

作者：

Dezulian, T ^{[1
]}

Remmert, M

Palatnik, JF

Weigel, D

Huson, DH

机构：

[1] Univ Tubingen, Ctr Bioinformat Tubingen, D-72074 Tubingen, Germany

[2] Max Planck Inst Dev Biol, Tubingen, Germany

来源：

BIOINFORMATICS | 2006年 / 22卷 / 03期

关键词：

D O I：

10.1093/bioinformatics/bti802

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs (miRNAs) are a recently discovered class of non-coding RNAs that regulate gene and protein expression in plants and animals. MiRNAs have so far been identified mostly by specific cloning of small RNA molecules, complemented by computational methods. We present a computational identification approach that is able to identify candidate miRNA homologs in any set of sequences, given a query miRNA. The approach is based on a sequence similarity search step followed by a set of structural filters.

引用

页码：359 / 360

页数：2

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