Dissociable hormonal, cognitive and mood responses to neuroendocrine challenge: Evidence for receptor-specific serotonergic dysregulation in depressed mood

被引:61
作者
Riedel, WJ
Klaassen, T
Griez, E
Honig, A
Menheere, PPCA
van Praag, HM
机构
[1] Univ Hosp Maastricht, Brain & Behav Inst, Dept Psychiat & Neuropsychol, Maastricht, Netherlands
[2] Univ Hosp Maastricht, Brain & Behav Inst, Dept Clin Chem, Maastricht, Netherlands
关键词
neuroendocrine; prolactin; cortisol; ACTH; serotonin; depression; memory;
D O I
10.1016/S0893-133X(01)00361-X
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Fifteen patients with major depression, dysthymia, or anxiety disorder with depressed mood (DSM-IV diagnoses) and 16 controls received single oral doses of 0.5mg/kg metachlorophenylpiperazine (m-CPP), a 5-HT2C agonist, and 10 mg ipsapirone, a 5-HT1A agonist, according to double-blind, placebo-con trolled, cross-over design. The groups' levels of cortisol, adrenocorticotrophic hormone (ACTH) and prolactin did not differ at baseline. Both 5-HT agonists signficantly elevated cortisol, ACTH, and prolactin. The cortisol response to ipsapirone was significantly blunted in major depression and dysthymia patients. Neuroendocrine responses to m-CPP did not differ between groups, but m-CPP selectively increased profile of mood states (POMS) depression and tenseness scores in patients. No effects of ipsapirone on mood were found. However, ipsapirone impaired memory performance in controls, but tended to improve memory peformance in patients. The results support the evidence for both hypothalamic and possibly hippocampal 5-HT1A receptor desensitisation and non-hypothalamic, 5-HT,c receptor sensitisation, probably fronto-cortical, in patients with major depression and dysthymia. (C) 2002 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.
引用
收藏
页码:358 / 367
页数:10
相关论文
共 34 条
[11]   PITUITARY-HORMONE RESPONSES TO META-CHLOROPHENYLPIPERAZINE IN PANIC DISORDER AND HEALTHY CONTROL SUBJECTS [J].
KAHN, RS ;
WETZLER, S ;
ASNIS, GM ;
KLING, MA ;
SUCKOW, RF ;
VANPRAAG, HM .
PSYCHIATRY RESEARCH, 1991, 37 (01) :25-34
[12]   BEHAVIORAL INDICATIONS FOR SEROTONIN RECEPTOR HYPERSENSITIVITY IN PANIC DISORDER [J].
KAHN, RS ;
WETZLER, S ;
VANPRAAG, HM ;
ASNIS, GM ;
STRAUMAN, T .
PSYCHIATRY RESEARCH, 1988, 25 (01) :101-104
[13]   NEURO-ENDOCRINE EVIDENCE FOR SEROTONIN RECEPTOR HYPERSENSITIVITY IN PANIC DISORDER [J].
KAHN, RS ;
ASNIS, GM ;
WETZLER, S ;
VANPRAAG, HM .
PSYCHOPHARMACOLOGY, 1988, 96 (03) :360-364
[14]   META-CHLOROPHENYLPIPERAZINE AS A PROBE OF SEROTONIN FUNCTION [J].
KAHN, RS ;
WETZLER, S .
BIOLOGICAL PSYCHIATRY, 1991, 30 (11) :1139-1166
[15]   Serotonin syndrome after challenge with the 5-HT agonist meta-chlorophenylpiperazine [J].
Klaassen, T ;
Pian, KLH ;
Westenberg, HGM ;
den Boer, JA ;
van Praag, HM .
PSYCHIATRY RESEARCH, 1998, 79 (03) :207-212
[16]  
LAWLOR BA, 1989, ARCH GEN PSYCHIAT, V46, P542
[17]   CORTICOTROPIN AND CORTISOL SECRETION AFTER CENTRAL 5-HYDROXYTRYPTAMINE-1A (5-HT1A) RECEPTOR ACTIVATION - EFFECTS OF 5-HT RECEPTOR AND BETA-ADRENOCEPTOR ANTAGONISTS [J].
LESCH, KP ;
SOHNLE, K ;
POTEN, B ;
SCHOELLNHAMMER, G ;
RUPPRECHT, R ;
SCHULTE, HM .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1990, 70 (03) :670-674
[18]   EFFECTS OF SEROTONIN PRECURSORS ON THE NEGATIVE FEEDBACK EFFECTS OF GLUCOCORTICOIDS ON HYPOTHALAMIC-PITUITARY-ADRENAL AXIS FUNCTION IN DEPRESSION [J].
MAES, M ;
MELTZER, HY ;
DHONDT, P ;
COSYNS, P ;
BLOCKX, P .
PSYCHONEUROENDOCRINOLOGY, 1995, 20 (02) :149-167
[19]  
Maes Michael, 1995, P933
[20]   Mood and neuropsychological function in depression: the role of corticosteroids and serotonin [J].
McAllister-Williams, RH ;
Ferrier, IN ;
Young, AH .
PSYCHOLOGICAL MEDICINE, 1998, 28 (03) :573-584