The EMT signaling pathways in endometrial carcinoma

被引：93

作者：

Colas, Eva ^{[1
,2
,3
]}

Pedrola, Nuria ^{[1
,2
,3
]}

Devis, Laura ^{[1
,2
,3
]}

Ertekin, Tugce ^{[1
,2
,3
]}

Campoy, Irene ^{[1
,2
,3
]}

Martinez, Elena ^{[1
,2
,3
]}

Llaurado, Marta ^{[1
,2
,3
]}

Rigau, Marina ^{[1
,2
,3
]}

Olivan, Mireia ^{[1
,2
,3
]}

Garcia, Marta ^{[1
,2
,3
]}

Cabrera, Silvia ^{[4
]}

Gil-Moreno, Antonio ^{[4
]}

Xercavins, Jordi ^{[4
]}

Castellvi, Josep ^{[5
]}

Garcia, Angel ^{[5
]}

Ramon y Cajal, Santiago ^{[5
]}

Moreno-Bueno, Gema ^{[6
,7
]}

Dolcet, Xavier ^{[8
]}

Alameda, Francesc ^{[9
]}

Palacios, Jose ^{[10
]}

Prat, Jaime ^{[11
]}

Doll, Andreas ^{[1
,2
,3
]}

Matias-Guiu, Xavier ^{[8
]}

Abal, Miguel ^{[12
]}

Reventos, Jaume ^{[1
,2
,3
,13
]}

机构：

[1] Vall dHebron Res Inst, Biomed Res Unit, Barcelona, Spain

[2] Univ Hosp, Barcelona, Spain

[3] Univ Autonoma Barcelona, E-08193 Barcelona, Spain

[4] Hosp Valle De Hebron, Serv Ginecol, Barcelona, Spain

[5] Hosp Valle De Hebron, Serv Patol, Barcelona, Spain

[6] IdiPAZ, Dept Bioquim IIB CSIC UAM, Madrid, Spain

[7] Fdn MD Anderson Int, Madrid, Spain

[8] Hosp Arnau Vilanova, Serv Patol, Lleida, Spain

[9] Hosp del Mar, Serv Patol, Barcelona, Spain

[10] Hosp Virgen del Rocio, Serv Patol, Seville, Spain

[11] Hosp Santa Creu & Sant Pau, Serv Patol, Barcelona, Spain

[12] Complejo Hosp Santiago de Compostela, Santiago De Compostela, Spain

[13] Univ Int Catalunya, Dept Ciencies Basiques, Barcelona, Spain

来源：

CLINICAL & TRANSLATIONAL ONCOLOGY | 2012年 / 14卷 / 10期

关键词：

Endometrial cancer; EMT; Invasion; EPITHELIAL-MESENCHYMAL TRANSITION; E-CADHERIN; PROGESTERONE-RECEPTOR; UP-REGULATION; BETA-CATENIN; MYOMETRIAL INFILTRATION; TRANSCRIPTION FACTOR; HORMONE-RECEPTORS; TUMOR PROGRESSION; OVARIAN-CANCER;

D O I：

10.1007/s12094-012-0866-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Endometrial cancer (EC) is the most common gynecologic malignancy of the female genital tract and the fourth most common neoplasia in women. In EC, myometrial invasion is considered one of the most important prognostic factors. For this process to occur, epithelial tumor cells need to undergo an epithelial to mesenchymal transition (EMT), either transiently or stably, and to differing degrees. This process has been extensively described in other types of cancer but has been poorly studied in EC. In this review, several features of EMT and the main molecular pathways responsible for triggering this process are investigated in relation to EC. The most common hallmarks of EMT have been found in EC, either at the level of E-cadherin loss or at the induction of its repressors, as well as other molecular alterations consistent with the mesenchymal phenotype-like L1CAM and BMI-1 up-regulation. Pathways including progesterone receptor, TGF beta, ETV5 and microRNAs are deeply related to the EMT process in EC.

引用

页码：715 / 720

页数：6

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