New thiazane and thiazolidine PNA monomers: Synthesis, incorporation into PNAs and hybridization studies

被引：8

作者：

Bregant, S ^{[1
]}

Burlina, F ^{[1
]}

Chassaing, GR ^{[1
]}

机构：

[1] Univ Paris 06, CNRS, UMR 7613, Lab Chim Organ Biol, F-75252 Paris 05, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(02)00076-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

New constrained PNA monomers containing a substituted thiazolidine or a thiazane ring were synthesized and incorporated in the center of a 9-mer homothymine PNA. The PNA/DNA hybrids stability was studied by UV-melting experiments which showed that the presence of the modified unit destabilizes the PNA/DNA triplexes. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1047 / 1050

页数：4

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