Constrained flexibility in PNA: DNA binding studies with bridged aminopropylglycyl PNA

被引:13
作者
Lonkar, PS [1 ]
Kumar, VA [1 ]
Ganesh, KN [1 ]
机构
[1] Natl Chem Lab, Div Organ Chem Synth, Pune 411008, Maharashtra, India
关键词
D O I
10.1081/NCN-100002518
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Introduction of methylene bridges in aegPNA and apgPNA molecules give rise to cyclic five and six membered ring structures. Synthesis of a new six membered cyclic PNA monomer, aminopipecolyl PNA (pipPNA) is reported. Incorporation of pipPNA into PNA oligomers and comparative binding with target DNA sequences is studied.
引用
收藏
页码:1197 / 1200
页数:4
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