Effects of superoxide dismutase/catalase mimetics on life span and oxidative stress resistance in the housefly, Musca domestica

被引：64

作者：

Bayne, ACV ^{[1
]}

Sohal, RS ^{[1
]}

机构：

[1] Univ So Calif, Dept Mol Pharmacol & Toxicol, Los Angeles, CA 90089 USA

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2002年 / 32卷 / 11期

关键词：

enzyme mimetics; aging; oxidative stress; antioxidant; catalase; superoxide dismutase; free radicals;

D O I：

10.1016/S0891-5849(02)00849-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The purpose of this study was to determine whether superoxide dismutase/catalase mimetics lengthen the life span of the housefly, Musca domestica, as previously demonstrated for the nematode Caenorhabditis elegans. Various concentrations of Eukarion-8 or Eukarion-134 were administered via the drinking water and the effects on the life span of the flies and amounts of protein carbonyls were determined under normoxic and hyperoxic conditions. These SOD/catalase mimetics neither extended the life span of the flies nor attenuated the protein carbonyl content under normoxic conditions and shortened life span under hyperoxic conditions. Thus, the effect of these SOD/catalase mimetics on the life span of animals seem to be species-specific. (C) 2002 Elsevier Science Inc.

引用

页码：1229 / 1234

页数：6

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