Extension of life-span with superoxide dismutase/catalase mimetics

被引：708

作者：

Melov, S

Ravenscroft, J

Malik, S

Gill, MS

Walker, DW

Clayton, PE

Wallace, DC

Malfroy, B

Doctrow, SR

Lithgow, GJ ^{[1
]}

机构：

[1] Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England

[2] Univ Manchester, Acad Unit Child Hlth, Manchester M13 9PT, Lancs, England

[3] Buck Inst Age Res, Novato, CA 94949 USA

[4] Eukarion, Bedford, MA 01730 USA

[5] Emory Univ, Ctr Mol Med, Atlanta, GA 30322 USA

来源：

SCIENCE | 2000年 / 289卷 / 5484期

关键词：

D O I：

10.1126/science.289.5484.1567

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We tested the theory that reactive oxygen species cause aging. We augmented the natural antioxidant systems of Caenorhabditis elegans with small synthetic superoxide dismutase/catalase mimetics. Treatment of wild-type worms increased their mean Life-span by a mean of 44 percent, and treatment of prematurely aging worms resulted in normalization of their life-span (a 67 percent increase). It appears that oxidative stress is a major determinant of Life-span and that it can be counteracted by pharmacological intervention.

引用

页码：1567 / 1569

页数：3

共 21 条

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