Dopaminergic Suppression of Brain Deactivation Responses during Sequence Learning

被引:57
作者
Argyelan, Miklos [1 ]
Carbon, Maren [1 ,2 ,3 ]
Ghilardi, Maria-Felice [4 ]
Feigin, Andrew [1 ,2 ,3 ]
Mattis, Paul [1 ,2 ,3 ]
Tang, Chengke [1 ,2 ,3 ]
Dhawan, Vijay [1 ,2 ,3 ]
Eidelberg, David [1 ,2 ,3 ]
机构
[1] N Shore Univ Hosp, Feinstein Inst Med Res, Ctr Neurosci, Manhasset, NY 11030 USA
[2] N Shore Univ Hosp, Dept Neurol, Manhasset, NY 11030 USA
[3] N Shore Univ Hosp, Dept Med, Manhasset, NY 11030 USA
[4] CUNY, Sch Med, Dept Physiol & Pharmacol, New York, NY 10031 USA
基金
美国国家卫生研究院;
关键词
levodopa; Parkinson's disease; sequence learning; deactivation; default mode network; COMT genotype;
D O I
10.1523/JNEUROSCI.2933-08.2008
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Cognitive processing is associated with deactivation of the default mode network. The presence of dopaminoceptive neurons in proximity to the medial prefrontal node of this network suggests that this neurotransmitter may modulate deactivation in this region. We therefore used positron emission tomography to measure cerebral blood flow in 15 Parkinson's disease (PD) patients while they performed a motor sequence learning task and a simple movement task. Scanning was conducted before and during intravenous levodopa infusion; the pace and extent of movement was controlled across tasks and treatment conditions. In normal and unmedicated PD patients, learning-related deactivation was present in the ventromedial prefrontal cortex (p < 0.001). This response was absent in the treated condition. Treatment-mediated changes in deactivation correlated with baseline performance (p < 0.002) and with the val(158)met catechol-O-methyltransferase genotype. Our findings suggest that dopamine can influence prefrontal deactivation during learning, and that these changes are linked to baseline performance and genotype.
引用
收藏
页码:10687 / 10695
页数:9
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