GS28, a 28-kilodalton Golgi SNARE that participates in ER-Golgi transport

被引：127

作者：

Subramaniam, VN ^{[1
]}

Peter, F ^{[1
]}

Philp, R ^{[1
]}

Wong, SH ^{[1
]}

Hong, WJ ^{[1
]}

机构：

[1] NATL UNIV SINGAPORE,INST MOLEC & CELL BIOL,MEMBRANE BIOL LAB,SINGAPORE 119260,SINGAPORE

来源：

SCIENCE | 1996年 / 272卷 / 5265期

关键词：

D O I：

10.1126/science.272.5265.1161

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Little is known about the integral membrane proteins that participate in the early secretory pathway of mammalian cells. The complementary DNA encoding a 28-kilodalton protein (p28) of the cis-Golgi was cloned and sequenced. The protein was predicted to contain a central coiled-coil domain with a carboxyl-terminal membrane anchor. An in vitro assay for endoplasmic reticulum-Golgi transport was used to show that p28 participates in the docking and fusion stage of this transport event. Biochemical studies established that p28 is a core component of the Golgi SNAP receptor (SNARE) complex.

引用

页码：1161 / 1163

页数：3