Metalated hybrid polymers as catalytic reagents for phosphate ester hydrolysis and plasmid modification

被引：20

作者：

Chandrasekhar, V ^{[1
]}

Deria, P ^{[1
]}

Krishnan, V ^{[1
]}

Athimoolam, A ^{[1
]}

Singh, S ^{[1
]}

Madhavaiah, C ^{[1
]}

Srivatsan, SG ^{[1
]}

Verma, S ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Kanpur 208016, Uttar Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 06期

关键词：

cyclophosphazene; pendant polymer; catalyst; zinc; phosphate ester; hydrolysis;

D O I：

10.1016/j.bmcl.2003.12.082

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Pendant pyrazolylcyclophosphazene containing hybrid cross-linked polymer (CPPL) has been utilized for binding Zn(II). The metalated polymer (CPPL-Zn) has been found to be very effective catalyst for the hydrolysis of a RNA model phosphodiester substrate [2-(hydroxypropyl)-p-nitrophenyl phosphate, hNPP]. In addition, CPPL-Zn also cleaved supercoiled plasmid DNA pBR322 thus providing a novel structural motif of inorganic-organic hybrid polymers as synthetic nucleases. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1559 / 1562

页数：4

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