Serum levels of the iron binding protein p97 are elevated in Alzheimer's disease

被引：138

作者：

Kennard, ML

Feldman, H

Yamada, T

Jefferies, WA

机构：

[1] UNIV BRITISH COLUMBIA, BIOTECHNOL LAB, VANCOUVER, BC V6T 1Z3, CANADA

[2] UNIV BRITISH COLUMBIA, DEPT MED GENET, VANCOUVER, BC V6T 1Z3, CANADA

[3] UNIV BRITISH COLUMBIA, DEPT MICROBIOL & IMMUNOL, VANCOUVER, BC V6T 1Z3, CANADA

[4] UNIV BRITISH COLUMBIA, DEPT ZOOL, VANCOUVER, BC V6T 1Z3, CANADA

[5] UNIV BRITISH COLUMBIA, VANCOUVER HOSP & HLTH SCI CTR, DEPT MED, DIV NEUROL, VANCOUVER, BC V6T 2B5, CANADA

[6] CHIBA UNIV, SCH MED, DEPT NEUROL, CHUO KU, CHIBA 260, JAPAN

来源：

NATURE MEDICINE | 1996年 / 2卷 / 11期

关键词：

D O I：

10.1038/nm1196-1230

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alzheimer's disease is a progressive and incurable disease whose prevalence increases dramatically with age. A biochemical marker for monitoring the onset and progression of the disease would be a valuable tool for disease management. In addition, such a marker might be used as an end point in clinical intervention protocols. Here we provide evidence that the soluble form of the iron binding protein p97 is found in elevated amounts in the serum of Alzheimer's patients compared with healthy controls. This biochemical marker has the potential for identifying subjects afflicted with the disease and possibly for monitoring the onset and longitudinal progression of the disease.

引用

收藏

页码：1230 / 1235

页数：6

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