Mutant KRAS, chromosomal instability and prognosis in colorectal cancer

被引：67

作者：

Castagnola, P ^{[1
]}

Giaretti, W ^{[1
]}

机构：

[1] Natl Inst Canc Res, I-16132 Genoa, Italy

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2005年 / 1756卷 / 02期

关键词：

KRAS; prognosis; colorectal cancer; chromosomal instability;

D O I：

10.1016/j.bbcan.2005.06.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The RAS gene family provides a global effect on gene expression by encoding small GTP-binding proteins which act as molecular switches connecting extracellular signals with nuclear transcription factors. While wild type RAS proteins are switched off shortly after activation, mutant RAS proteins remain constitutively activated leading to complex interactions among their downstream effectors. For some human tumor types, these interactions were shown to contribute to cancer genesis and progression by inducing changes in cell survival, apoptosis, angiogenesis, invasion and metastasis. This review addresses the controversial link of KRAS mutations in colorectal cancer with chromosomal instability and patient prognosis. (c) 2005 Elsevier B.V. All rights reserved.

引用

收藏

页码：115 / 125

页数：11

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