Successful treatment of oxidative stress in vitiligo

被引：56

作者：

Schallreuter, KU ^{[1
]}

机构：

[1] Univ Bradford, Dept Biomed Sci, Bradford BD7 1DP, W Yorkshire, England

来源：

SKIN PHARMACOLOGY AND APPLIED SKIN PHYSIOLOGY | 1999年 / 12卷 / 03期

关键词：

vitiligo; hydrogen peroxide; pseudocatalase; calcium; UVB;

D O I：

10.1159/000029867

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Patients with vitiligo have low catalase levels in their involved and uninvolved epidermis in association with high levels of hydrogen peroxide (H2O2). H2O2 has been confirmed for the first time in vivo using Fourier Transform Raman spectroscopy. A topical substitution with a UVB-activated pseudocatalase can successfully remove epidermal H2O2 in vitiligo. This approach leads to recovery of the oxidative damage in the epidermis and remarkable repigmentation in this disorder.

引用

页码：132 / 138

页数：7

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