Umbilical Cord-Derived Mesenchymal Stem Cells Suppress Autophagy of T Cells in Patients with Systemic Lupus Erythematosus via Transfer of Mitochondria

被引：39

作者：

Chen, Jinyun ^{[1
]}

Wang, Qian ^{[2
]}

Feng, Xuebing ^{[1
]}

Zhang, Zhuoya ^{[1
]}

Geng, Linyu ^{[1
]}

Xu, Ting ^{[3
]}

Wang, Dandan ^{[1
]}

Sun, Lingyun ^{[1
]}

机构：

[1] Nanjing Univ Med Sch, Affiliated Drum Tower Hosp, Dept Rheumatol & Immunol, Nanjing 210008, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Drum Tower Clin Med Coll, Dept Rheumatol & Immunol, Nanjing 210008, Jiangsu, Peoples R China

[3] Soochow Univ, Affiliated Hosp 3, Dept Rheumatol & Immunol, Suzhou 215006, Jiangsu, Peoples R China

来源：

STEM CELLS INTERNATIONAL | 2016年 / 2016卷

基金：

中国国家自然科学基金;

关键词：

DEATH; APOPTOSIS; AUTOIMMUNITY; INDUCTION; PROMOTES; THERAPY; MIRO1;

D O I：

10.1155/2016/4062789

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Aberrant autophagy played an important role in the pathogenesis of autoimmune diseases, especially in systemic lupus erythematosus (SLE). In this study, we showed that T cells from SLE patients had higher autophagic activity than that from healthy controls. A correlation between autophagic activity and apoptotic rate was observed in activated T cells. Moreover, activation of autophagy with rapamycin increased T cell apoptosis, whereas inhibition of autophagy with 3-MA decreased T cell apoptosis. Umbilical cord-derived mesenchymal stem cells (UC-MSCs) could inhibit respiratory mitochondrial biogenesis in activated T cells to downregulate autophagy and consequently decrease T cell apoptosis through mitochondrial transfer and thus may play an important role in SLE treatment.

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