Fibrinolytic poly(dimethyl siloxane) surfaces

被引：43

作者：

Chen, Hong ^{[1
,2
]}

Wang, Liang ^{[1
,2
]}

Zhang, Yanxia ^{[1
,2
]}

Li, Dan ^{[1
,2
]}

McClung, W. Glenn ^{[3
,4
]}

Brook, Michael A. ^{[5
]}

Sheardown, Heather ^{[3
,4
]}

Brash, John L. ^{[3
,4
]}

机构：

[1] Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R China

[2] Wuhan Univ Technol, Sch Mat Sci & Engn, Wuhan 430070, Peoples R China

[3] McMaster Univ, Sch Biomed Engn, Hamilton, ON, Canada

[4] McMaster Univ, Dept Chem Engn, Hamilton, ON L8S 4L7, Canada

[5] McMaster Univ, Dept Chem, Hamilton, ON, Canada

来源：

MACROMOLECULAR BIOSCIENCE | 2008年 / 8卷 / 09期

基金：

加拿大健康研究院;

关键词：

biocompatibility; fibrinolytic property; poly(ethylene glycol) (PEG); polysiloxanes; protein adsorption;

D O I：

10.1002/mabi.200800014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

PDMS surfaces have been modified to confer both resistance to non-specific protein adsorption and clot lyzing properties. The properties and chemical compositions of the surfaces have been investigated using water contact angle measurements, ATR FT-IR spectroscopy, and XPS. The ability of the PEG component to suppress non-specific protein adsorption was assessed by measurement of radiolabeled fibrinogen uptake from buffer. The adsorption of plasminogen from human plasma to the various surfaces was studied. In vitro experiments 70 demonstrated that lysine-immobilized surfaces with free P-amino groups were able to dissolve fibrin clots, following exposure to plasma and tissue plasminogen activator.

引用

页码：863 / 870

页数：8

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