Mast Cells Multifaceted Immune Cells with Diverse Roles in Health and Disease

被引:202
作者
Rao, Kavitha N. [1 ]
Brown, Melissa A. [1 ]
机构
[1] Northwestern Univ, Feinberg Sch Med, Dept Microbiol & Immunol, Chicago, IL 60611 USA
来源
YEAR IN IMMUNOLOGY 2008 | 2008年 / 1143卷
关键词
mast cells; degranulation; allergy; homeostasis; tissue remodeling; autoimmune disease; multiple sclerosis; rheumatoid arthritis; cardiovascular disease; cancer;
D O I
10.1196/annals.1443.023
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Mast cells were discovered more than 100 years ago and until recently, have been considered renegades of the host with the sole purpose of perpetuating allergy. The discovery of mast cell-deficient mice that could be reconstituted with mast cells (the so called "mast cell knock-in" mice) has allowed the study of the in vivo functions of mast cells and revealed several new facets of these cells. It is now evident that mast cells have a much broader impact on many physiological and pathologic processes. Mast cells, particularly through their dynamic interaction with the nervous system, have been implicated in wound healing, tissue remodeling, and homeostasis. Perhaps the most progress has been made in our understanding of the role of mast cells in immunity outside the realm of allergy, and host defense. Mast cells play critical roles in both innate and adaptive immunity, including immune tolerance. Greater insight into mast cell biology has prompted studies probing the additional consequences of mast cell dysfunction, which reveal a central role for mast cells in the pathogenesis of autoimmune disorders, cardiovascular disorders, and cancer. Here, we review recent developments in the study of mast cells, which present a complex picture of mast cell functions.
引用
收藏
页码:83 / 104
页数:22
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