Antiproliferative and Hypoglycemic Cucurbitane-Type Glycosides from the Fruits of Momordica charantia

被引：71

作者：

Hsiao, Ping-Chun ^{[1
,2
]}

Liaw, Chia-Ching ^{[3
]}

Hwang, Syh-Yuan ^{[4
]}

Cheng, Hui-Ling ^{[1
]}

Zhang, Li-Jie ^{[1
]}

Shen, Chien-Chang ^{[1
]}

Hsu, Feng-Lin ^{[2
]}

Kuo, Yao-Haur ^{[1
,5
]}

机构：

[1] Natl Res Inst Chinese Med, Div Herbal Drugs & Nat Prod, Taipei 112, Taiwan

[2] Taipei Med Univ, Grad Inst Pharmacognosy, Taipei 110, Taiwan

[3] Starsci Biotech Co Ltd, Taipei 112, Taiwan

[4] Council Agr, Endem Species Res Inst, Nantou 552, Taiwan

[5] China Med Univ, Grad Inst Integrated Med, Taichung 404, Taiwan

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2013年 / 61卷 / 12期

关键词：

Momordica charantia; cucurbitane; triterpene glycosides; kuguaoside; antiproliferative activity; hypoglycemic activity; TRITERPENE GLYCOSIDES; BITTER-MELON; CONSTITUENTS;

D O I：

10.1021/jf3041116

中图分类号：

S [农业科学];

学科分类号：

082806 [农业信息与电气工程];

摘要：

This paper reports that bioassay-guided fractionations of EtOH extract of Momordica charantia fruits led to the isolation of 15 cucurbitane-type triterpene glycosides including 4 new compounds, kuguaosides A-D (1-4), along with 11 known ones, charantoside A (5), momordicosides 1(6), F-1 (7), F-2 (8), K (9), L (10), and U (11), goyaglycosides-b (12) and -d (13), 7 beta,25-dihydroxycucurbita-5,23(E)-dien-19-al 3-O-beta-D-allopyranoside (14), and 25-hydroxy-5 beta,19-epoxycucurbita-6,23-dien-19-on-3 beta-ol 3-O-beta-D-glucopyranoside (15). Their structures were elucidated on the basis of spectroscopic analyses and chemical methods. This study also established the HPLC-ELSD fingerprinting profile of an antiproliferative fraction of which 11 main peaks were identified. Biological evaluation showed that several isolated cucurbitane-type triterpene glycosides had antiproliferative activities against MCF-7, WiDr, HEp-2, and Doay human tumor cell lines. In addition, compound 14 showed potent hypoglycemic activities by glucose uptake assay.

引用

页码：2979 / 2986

页数：8

共 26 条

[1]

Cucurbitane-type triterpenoids from the fruits of Momordica charantia and their cancer chemopreventive effects [J].

Akihisa, Toshihiro ;

Higo, Naoki ;

Tokuda, Harukuni ;

Ukiya, Motohiko ;

Akazawa, Hiroyuki ;

Tochigi, Yuichi ;

Kimura, Yumiko ;

Suzuki, Takashi ;

Nishino, Hoyoku .

JOURNAL OF NATURAL PRODUCTS, 2007, 70 (08) :1233-1239

[2]

POTENTIATION OF ANTI-HIV ACTIVITY OF ANTIINFLAMMATORY DRUGS, DEXAMETHASONE AND INDOMETHACIN, BY MAP30, THE ANTIVIRAL AGENT FROM BITTER-MELON [J].

BOURINBAIAR, AS ;

LEEHUANG, S .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 208 (02) :779-785

[3]

Chen C. H., 1993, FLORA TAIWAN, V3, P855

[4]

Kuguacins F-S, cucurbitane triterpenoids from Momordica charantia [J].

Chen, Jian-Chao ;

Liu, Wu-Qing ;

Lu, Lu ;

Qju, Ming-Hua ;

Zheng, Yong-Tang ;

Yang, Liu-Meng ;

Zhang, Xian-Min ;

Zhou, Lin ;

Li, Zhong-Rong .

PHYTOCHEMISTRY, 2009, 70 (01) :133-140

[5]

Trinorcucurbitane and cucurbitane triterpenoids from the roots of Momordica charantia [J].

Chen, Jianchao ;

Tian, Renrong ;

Qiu, Minghua ;

Lu, Lu ;

Zheng, Yongtang ;

Zhang, Zhongquan .

PHYTOCHEMISTRY, 2008, 69 (04) :1043-1048

[6]

HYPOGLYCEMIC EFFECT OF MOMORDICA-CHARANTIA EXTRACTS [J].

DAY, C ;

CARTWRIGHT, T ;

PROVOST, J ;

BAILEY, CJ .

PLANTA MEDICA, 1990, 56 (05) :426-429

[7]

Pharmacological actions and potential uses of Momordica charantia:: a review [J].

Grover, JK ;

Yadav, SP .

JOURNAL OF ETHNOPHARMACOLOGY, 2004, 93 (01) :123-132

[8]

JILKA C, 1983, CANCER RES, V43, P5151

[9]

Dietary conjugated linolenic acid inhibits azoxymethane-induced colonic aberrant crypt foci in rats [J].

Kohno, H ;

Suzuki, R ;

Noguchi, R ;

Hosokawa, M ;

Miyashita, K ;

Tanaka, T .

JAPANESE JOURNAL OF CANCER RESEARCH, 2002, 93 (02) :133-142

[10]

Terpenoids from Guarea guidonia [J].

Lago, JHG ;

Brochini, CB ;

Roque, NF .

PHYTOCHEMISTRY, 2002, 60 (04) :333-338

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