Trinorcucurbitane and cucurbitane triterpenoids from the roots of Momordica charantia

被引：88

作者：

Chen, Jianchao ^{[1
,3
]}

Tian, Renrong ^{[2
]}

Qiu, Minghua ^{[1
]}

Lu, Lu ^{[1
,3
]}

Zheng, Yongtang ^{[2
]}

Zhang, Zhongquan ^{[1
,3
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China

[2] Chinese Acad Sci, Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China

[3] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

来源：

PHYTOCHEMISTRY | 2008年 / 69卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Momordica charantia; Cucurbitaceae; roots; kuguacins A-E; trinorcucurbitane triterpenoids; anti-HIV-1;

D O I：

10.1016/j.phytochem.2007.10.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Five cucurbitacins, kuguacins A-E (1-5), together with three known analogues, 3 beta,7 beta,25-trihydroxycucurbita-5,(23E)-diene-19-al (6), 3 beta,25-dihydroxy-5 beta,19-epoxycucurbita-6,(23E)-diene (7), and momordicine I (8), were isolated from roots of Momordica charantia. Structures of 1-5 were elucidated by NMR and MS spectroscopic analysis. Among them, compounds 3-5 possess an unprecedented 25,26,27-trinorcucurbitane backbone. Compounds 3 and 5 showed moderate anti-HIV-1 activity with EC50 values of 8.45 and 25.62 mu g/ml, and exerted minimal cytotoxicity against C8166 cells (IC50 > 200 mu g/ml), with a selectivity index more than 23.68 and 7.81, respectively. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：1043 / 1048

页数：6

共 17 条

[1]

7-OXO-10-ALPHA-CUCURBITADIENOL FROM THE SEEDS OF TRICHOSANTHES KIRILOWII AND ITS ANTIINFLAMMATORY EFFECT [J].