Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals

被引：209

作者：

Zhang, Yong-Hong ^{[1
]}

Zhao, Yan ^{[1
]}

Li, Ning ^{[1
]}

Peng, Yan-Chun ^{[2
]}

Giannoulatou, Eleni ^{[3
]}

Jin, Rong-Hua ^{[1
]}

Yan, Hui-Ping ^{[1
]}

Wu, Hao ^{[1
]}

Liu, Jin-Hua ^{[1
]}

Liu, Ning ^{[1
]}

Wang, Da-Yan ^{[4
]}

Shu, Yue-Long ^{[4
]}

Ho, Ling-Pei ^{[2
,5
]}

Kellam, Paul ^{[6
,7
]}

McMichael, Andrew ^{[2
]}

Dong, Tao ^{[1
,2
]}

机构：

[1] Capital Med Univ, Beijing Youan Hosp, Beijing 100069, Peoples R China

[2] Univ Oxford, MRC Human Immunol Unit, Weatherall Inst Mol Med, Oxford OX3 9DS, England

[3] Univ Oxford, Computat Biol Res Grp, Weatherall Inst Mol Med, Oxford OX3 9DS, England

[4] China CDC, Chinese Natl Influenza Ctr, Natl Inst Viral Dis Control & Prevent, Beijing 102206, Peoples R China

[5] Oxford Univ Hosp NHS Trust, Oxford Ctr Resp Med, Headington OX3 7LH, Oxon, England

[6] Wellcome Trust Genome Campus, Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England

[7] UCL, UCL MRC Ctr Med Mol Virol, Res Dept Infect, Div Infect & Immun, London WC1E 6BT, England

来源：

NATURE COMMUNICATIONS | 2013年 / 4卷

基金：

北京市自然科学基金; 英国惠康基金; 中国国家自然科学基金; 英国医学研究理事会;

关键词：

VIRUS; INFECTION; IFITM3; H5N1;

D O I：

10.1038/ncomms2433

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The SNP rs12252-C allele alters the function of interferon-induced transmembrane protein-3 increasing the disease severity of influenza virus infection in Caucasians, but the allele is rare. However, rs12252-C is much more common in Han Chinese. Here we report that the CC genotype is found in 69% of Chinese patients with severe pandemic influenza A H1N1/09 virus infection compared with 25% in those with mild infection. Specifically, the CC genotype was estimated to confer a sixfold greater risk for severe infection than the CT and TT genotypes. More importantly, because the risk genotype occurs with such a high frequency, its effect translates to a large population-attributable risk of 54.3% for severe infection in the Chinese population studied compared with 5.4% in Northern Europeans. Interferon-induced transmembrane protein-3 genetic variants could, therefore, have a strong effect of the epidemiology of influenza in China and in people of Chinese descent.

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