Engineering H5N1 avian influenza viruses to study human adaptation

被引：43

作者：

Morens, David M. ^{[1
]}

Subbarao, Kanta ^{[1
]}

Taubenberger, Jeffery K. ^{[1
]}

机构：

[1] NIAID, NIH, Bethesda, MD 20892 USA

来源：

NATURE | 2012年 / 486卷 / 7403期

基金：

美国国家卫生研究院;

关键词：

A VIRUSES; RECEPTOR SPECIFICITY; MOUSE MODEL; VIRULENCE DETERMINANTS; SWINE INFLUENZA; CLEAVAGE SITE; TRANSMISSION; HEMAGGLUTININ; FERRETS; REPLICATION;

D O I：

10.1038/nature11170

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Two studies of H5N1 avian influenza viruses that had been genetically engineered to render them transmissible between ferrets have proved highly controversial. Divergent opinions exist about the importance of these studies of influenza transmission and about potential 'dual use' research implications. No consensus has developed yet about how to balance these concerns. After not recommending immediate full publication of earlier, less complete versions of the studies, the United States National Science Advisory Board for Biosecurity subsequently recommended full publication of more complete manuscripts; however, controversy about this and similar research remains.

引用

页码：335 / 340

页数：6

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