RNA binding and translational suppression by bicoid

被引：256

作者：

RiveraPomar, R ^{[1
]}

Niessing, D ^{[1
]}

SchmidtOtt, U ^{[1
]}

Gehring, WJ ^{[1
]}

Jackle, H ^{[1
]}

机构：

[1] UNIV BASEL,BIOZENTRUM,CH-4056 BASEL,SWITZERLAND

来源：

NATURE | 1996年 / 379卷 / 6567期

关键词：

D O I：

10.1038/379746a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

THE anterior determinant bicoid (bcd) of Drosophila is a homeodomain protein. It forms an anterior-to-posterior gradient in the embryo and activates, in a concentration-dependent manner, several zygotic segmentation genes during blastoderm formation(1-4). Its posterior counterpart, the homeodomain transcription factor caudal (cad)(5-7), forms a concentration gradient in the opposite direction, emanating from evenly distributed messenger RNA in the egg. In embryos lacking bcd activity as a result of mutation, the cad gradient fails to form and cad becomes evenly distributed throughout the embryo(8). This suggests that bcd may act in the region-specific control of cad mRNA translation. Here we report that bcd binds through its homeodomain to cad mRNA in vitro, and exerts translational control through a bcd-binding region of cad mRNA.

引用

页码：746 / 749

页数：4

共 29 条

[11]

MLODZIK M, 1987, DEVELOPMENT, V101, P421

[12] ISOLATION OF CAUDAL, A DROSOPHILA HOMEO BOX-CONTAINING GENE WITH MATERNAL EXPRESSION, WHOSE TRANSCRIPTS FORM A CONCENTRATION GRADIENT AT THE PRE-BLASTODERM STAGE [J].